Cimetidine-associated mental confusion

Gynaecomastia associated with cimetidine.

Gynaecomastia has occurred unilaterally or bilaterally in five out of 25 male duodenal ulcer patients after more than four months treatment with cimetidine 1.6 g daily. All elected to continue treatment to 12 months and their breast enlargement regressed rapidly and disappeared after stopping treatment. During treatment all patients were found to have normal concentrations of plasma testosteron...

Renal failure, mental retardation and eponymous confusion

Hereditary renal failure includes a wide spectrum of diseases, ranging from the well-known autosomal-dominant polycystic kidney disease (ADPKD) to rare syndromes. The latter group includes a broad variety of diseases, often with a whole host of extra-renal manifestations. Many of these syndromes are little known among adult nephrologists, be it simply because they are rare, or due to the fact t...

Levothyroxine, mental confusion and suicide attempt.

Polyuria and weight-loss associated with cimetidine.

Confusion and paranoia associated with oral tocainide.

Two middle aged female patients developed hallucinations and severe confusion with paranoid features during oral tocainide administration at recommended dosage levels. Both patients had evidence of impaired renal function. Symptoms were provoked on re-challenge in the first patient. In the second patient the tocainide blood level was higher than the recommended therapeutic range. Both patients ...